|
KMID : 1036920120170010010
|
|
Annals of Pediatric Endocrinology & Metabolism
2012 Volume.17 No. 1 p.10 ~ p.15
|
|
|
Insulin-Like Growth Factor 1 Actions in Developing Brain and the Interaction with Wnt Pathway
|
|
Lee Seong-Yong
|
|
|
Abstract
|
|
|
|
Insulin like growth factor (IGF)-1 signaling through type 1 IGF receptor (IGF1R) is essential to the normal growth and development of the central nervous system. IGF-1 stimulates proliferation of neural stem cells and neural progenitors. IGF-1 also promotes survival and differentiation of neurons and oligodendrocytes, including neuritic outgrowth, synaptogenesis, and myelin production. The phosphatidylinositol 3 kinase (PI3)-Akt pathway and mitogen-activated protein (MAP) kinase pathway are two predominant mediators of IGF1-IGF1R signaling in neural cells. β-catenin, a key molecule of the canonical Wnt signaling pathway, is also a downstream target of PI3-Akt-glycogen synthase kinase 3β (GSK3β) pathway. IGF-1 signaling through IGF1R interacts with canonical Wnt pathway at the levels of GSK3β and β-catenin rather than at the levels of Wnt ligands and Frizzled receptors to promote neural proliferation in developing central nervous system.
|
|
|
KEYWORD
|
|
|
Insulin-like growth factor I, Type 1 IGF receptor, Wnt proteins, Beta catenin, Central nervous system
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|